I recently stated in “Upcoming events” I would return and post media accompanying the event and after a long delay here is my update.
First was the radio interview where I appeared live on BBC Radio Lincolnshire with Yasmin interviewed by Leigh Milner as tweeted here. Speaking on the radio was a great experience as well as nerve-racking one which I definitely would do again given the chance. The offline broadcast can be listened via Youtube using the embedded video below:
Regards to David Barnett for uploading the interview on my behalf.
Secondly in the Upcoming events post, I mentioned about the University of Lincoln Life Sciences conference where I presented the research I carried out during my final year dissertation project. I really enjoyed the conference and it was a good opportunity to look at fellow students projects as well as present my own project. I have attached an image of myself and the poster taken after the conference below:
There are some big events coming up which I am really looking forward to.
Firstly I will be live on air on BBC radio Lincolnshire, Monday 19th May at 8:50am discussing my undergraduate experience at the University of Lincoln and my plans for the future. I am really looking forward to the experience and I hope you can listen live. An offline version after the broadcast will be made available which I will link as soon as possible.
Secondly, there is a conference at the beginning of June (2nd-3rd) where undergraduates from the University of Lincoln can present there independent research project work. The conference will be a 2 day event open to the public where Monday will be biomedical science and forensic science presentations and Tuesday will focus on biological sciences such as nutrition, animals and plants. I will be presenting Monday morning and the event is being held in the Engine Shed on the University of Lincoln Brayford campus. The research I will be presenting was mentioned in a previous blog post here.
Currently I have my final exams so a lot of my time is dedicated revision where my final exam is on the 4th of June.
During my third year, I was given the opportunity to be the treasurer of the University of Lincoln Society of Life Sciences (ULSoLS). The idea of the ULSoLS is to promote various life science disciplines available at the University of Lincoln from engineering to veterinary science. One of the extra opportunities I was involved in was the production and editing of a 50 minute presentation by Dr. Colin Dowding. His presentation was on the principles of high power lasers and there interactions with materials. Watch the video below and please check out ULSoLS page for more updates and events!
It has been a while since I have updated due to various time commitments of being a third year student from various core modules to the third year dissertation project.
Currently, there are only a few weeks left till the dissertation deadline but I am looking forward to producing my first, hopefully of many, publications using research I have carried out. The dissertation project I am focused on involves neurotensin receptors 1 (NTS1) being over expressed in breast cancer cells. A paper by Vandebulcke et al. (2000) has shown the uptake of neurotensin-GFP fusion into COS-7 breast cancer cells which allows the way for possible targeted drug delivery applications. My project is focusing on the cloning of neurotensin-double GFP fusions using PCR techniques to test the size of the endocytosis uptake by the NTS1 GPCR receptors expressed on COS-7 cells. My supervisor for this project is Dr. Alan Goddard.
Neurotensin receptors are expressed naturally on other tissues mainly in the central nervous system (CNS) shown by Uhl et al. (1977) in rat central nervous system. Targeting and administration of these neurotensin-drug fusions should not enter the CNS due to various efflux receptors, most commonly noted in the blood brain barrier, so theoretically neurotensin offers a unique target for drug delivery. An interesting fusion could be the use of interferon (IFN) alpha with the ability to act as an anti-viral agents which inhibits replication and has shown promise in current cancer treatment (Ferrantini et al., 2007; Zaidi and Merlino, 2011). Due to IFN-alpha protein structure, fusions with neurotensin may be a possible payload to delivery to COS-7 cells.
I am presenting my work via poster at the ‘University of Lincoln Undergraduate Life Sciences Conference 2014’, dates: TBA expected early June. I will post an update when more information becomes available.
Ferrantini, M., Capone, I., and Belardelli, F. (2007) Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. Biochimie, 89(6-7), pp. 884-893.
Uhl, G.R.; Kuhar, M.J.; Snyder, S.H. (1977) Neurotensin: immunohistochemical localization in rat central nervous system. Proceedings of the National Academy of Sciences of the United States of America, 74(9), pp. 4059-4063.
Vandenbulcke, F., Nouel, D., Vincent, J.P., Mazella, J., and Beaudet, A. (2000) Ligand-induced internalization of neurotensin in transfected COS-7 cells: differential intracellular trafficking of ligand and receptor. Journal of Cell Science, 113 ( Pt 17)(Pt 17), pp. 2963-2975.
Zaidi, M.R. and Merlino, G. (2011) The two faces of interferon-gamma in cancer. Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 17(19), pp. 6118-6124.
Hello, I am a 2nd year student currently at the University of Lincoln studying BSc Biomedical Science (Hons). My passion is to enter nanomedicine hence the title of the blog and this is going to be a blog about my experiences from the highs and lows as I hopefully reach my goal of becoming a nanomedic or at the very least entering the nanomedicine field.
Currently my aim is to graduate and enter a PhD in nanoscience, specifically nanomedicine, within the UK.